A Novel Mutation in the TATA Box in a Japanese Patient With fl-Thalassemia
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چکیده
A single base substitution (A-G) at position 31 within the highly conserved proximal promoter element. the TATA box, was identified in the fi-globin gene cloned from a Japanese woman with fl -thalassemia. It appears that she is homozygous for this specific allele, as determined by haplotype analysis using seven different polymorphic sites in the fl-globin gene cluster. Transient expression of the
منابع مشابه
A novel mutation in the TATA box in a Japanese patient with beta +-thalassemia.
A single base substitution (A-G) at position -31 within the highly conserved proximal promoter element, the TATA box, was identified in the beta-globin gene cloned from a Japanese woman with beta +-thalassemia. It appears that she is homozygous for this specific allele, as determined by haplotype analysis using seven different polymorphic sites in the beta-globin gene cluster. Transient express...
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تاریخ انتشار 2005